The breast is various target organs of endocrine, internal secretion hormones, therefore, breast growth and development and it various physiology function of exertive all depend on the common action of various related endocrine, internal secretion hormone.If among them a certain or a few hormone secret mess, or the equilibrium detuning of of various hormone, by all means will directly or indirectly affect condition and its physiology function of mammary gland.
(1)Take place the hormone of direct action to the mammary gland
Estrogenic hormone:(estrogen, E)Mainly from the ovarian follicle secret of ovary, adrenal gland and testis may also secrete a little amount estrogenic hormone and the estrogenic hormone of anaphase then mainly comes from the chorion epithelium of placenta in the pregnancy.Physiology in the estrogenic hormone the live estradiol, E2(E2) be most strong.At the youth development phase, the ovarian follicle of ovary is mature, start secrete a great deal of estrogenic hormone, the estrogenic hormone can promote the epithelium hyperplasis of mammary gland catheter, the mammary ridge take care of and the connective tissue development of the leaflet surroundings, make the mammary ridge palatine canal prolong and cent.The estrogenic hormone becomes lobules of mammary gland and the mammary gland be mature, can’t produce result alone, have to have a complete hypophysis, pituitary gland function the control of the system.The estrogenic hormone can stimulate the hypophysis, pituitary gland ex- leaf, frond synthesis with release a prolactin, PRL, promote the development of mammary gland thus;But the estrogenic hormone of big dose can compete prolactin, PRL receptor again, repress the action of Bi mammary ridge of prolactin, PRL thus.At the gestation period, estrogenic hormone at other hormones such as under the synergetic activity of lutein etc. can also promote development and human milk of acinus of born.The outside and source estrogenic hormone can make the hyperplasis is to the mammary gland tissue of the ovary animal and its cell proliferation index number is obviously high to organize at the normal mammary gland.The estrogenic hormone can also make the mammary gland vasodilator, permeability increase.
Progestogen:(progesterone, P)Call lutein again, mainly from ovary corpus luteum secret, the gestation period is secrete by the placenta.What to have physiology enzyme activity most is a progesterone in the progestogen, it cardinal action for promote the development of lobules of mammary gland and acinus, stimulate mammary gland catheter the basal of the development in the estrogenic hormone up, make the mammary gland get a full development.The progestogen of big dose represses the action of Bi mammary ridge of prolactin, PRL.The influence of the progestogen upon the mammary gland development have to not only have the synergetic activity of estrogenic hormone, but also have to also have a complete hypophysis, pituitary gland function a system.The experiment express that is cut off the desexualination big rat of hypophysis, pituitary gland, the mammary gland completely lacks the reaction toward the progesterone.The progestogen may be to pass the secret prolactin, PRL of the stimulation hypophysis, pituitary gland, be also likely to be pass exaltation mammary ridge glandular epithelium cell to prolactin, PRL of reaction but together complete with it to the development action of mammary gland.
Prolactin, PRL:(prolactin, PRL)From the hypophysis, pituitary gland ex- protein hormone of a species of the secret of the leaf, frond acidophile.It cardinal action in order to help the mammary gland development to grow, launch demulcent therapy, reconciliation maintenance Bi mammary ridge.The PRL receptor of prolactin, PRL and mammary ridge glandular epithelium cell combine, produce a series reaction and include a synthesis of stimulate the ? -lactalbumin, uridine glycoside an acid a transition, the mammary ridge glandular cell Na ? +the synthesis of the transition and fatty acids of ion, stimulation mammary gland acinus development and promote human milk of born with secret.At the youth development phase, the prolactin, PRL can urge a mammary gland development under the common action of the estrogenic hormone, progestogen and other hormones;Can make the mammary gland get a full development in the gestation period, make lobules of mammary gland eventually the end catheter development become small acinus and make good preparation for the lactation.The gestation period is in great quantities female and the progestogen repressed the action of Bi mammary ridge of prolactin, PRL;After give birth to baby, female, the progestogen level quickly descend, relieved to the inhibition of prolactin, PRL, the secret of prolactin, PRL also in great quantities increases in the meantime, the mammary gland beginning Bi mammary ridge.Henceforth, along with regulation ground establishment for breast feed, the infant constantly sucks up nipple but creation reflex, stimulate ex- the hypophysis, pituitary gland a leaf, frond secret a prolactin, PRL, can make thus the Bi mammary ridge maintain few months to few years.The secret of prolactin, PRL be subjected to the enzyme regulation of the inhibition rho factor of the hypothalamus prolactin, PRL and prolactin releasing factor, PRF and other hormones.Levodopa and the bromine concealed station etc. drug can repress the secret of prolactin, PRL;The Cu thyroid gland releases hormone, 5-the Qian color amine and some drugs(like the benefit blood calm, chloropromazine) etc.s can promote the secret of prolactin, PRL;The estrogenic hormone, progestogen of small dose can help the hypophysis, pituitary gland to secrete prolactin, PRL, but the estrogenic hormone, progestogen of big dose can then repress the secret of prolactin, PRL.
(2)To mammary gland since the hormone of indirect action
The ovarian follicle stimulates a vegetable:(follicle-stimulating hormone, FSH)It is secrete by the hypophysis, pituitary gland ex- leaf, frond.In order to stimulate ovary secret estrogenic hormone, the cardinal action develops mammary gland thus and the enzyme regulation vesication of the physiology function indirect action.
Cu luteinizing hormone:(luteinizing hormone, LH)It is secrete by the hypophysis, pituitary gland ex- leaf, frond.The cardinal action is a stimulation creation lutein, develop mammary gland thus and the enzyme regulation of the physiology function vesication indirect action.
Oxytocin(oxytocin):It is secreted after the hypophysis, pituitary gland by the leaf, frond.BE breast feed expect have already helped the human milk to eject of action.
Androgen(androgen):At the female is secrete by the adoptive cortex since then.The sterigma can promote the development of mammary gland when the sterigma measure;But can then rise inhibition for a great deal of hour.
Other hormones:Such as the somatotropin(growth hormone, GN), adrenal cortical hormone, corticoid(adrenocortico-hormo ne), thyroxine(thyroxine) and insulin(insulin) etc., these hormone to development and various function activity of mammary gland since indirect action.
Sep
05
By: Gelais
