Certain gene mutation might increase the woman to contract ovarian cancer’s risk, Narod and so on carries on a case to compare the research, discovered that the two-sided oviduct ligation might reduce the BRCA1 sudden change woman to contract ovarian cancer’s danger. The woman contracts the attack ovarian cancer’s life-long danger is 1/70. Carries certain mutant gene (BRCA1 or BRCA2) contracts the ovarian cancer danger to increase (40% obviously and 25%). Has these sudden change woman diagnoses for the ovarian cancer when usually to be young, and is in disease later period. Until now still did not have the screening ovarian cancer’s reliable method, especially before the menopause woman. The research indicated that the oral contraceptive may reduce has or does not have these sudden change woman’s ovarian cancer danger. The preventive ovary excision method is many BRCA1 or the BRCA2 gene mutation woman, after completing the birth, may choose another prevention ovarian cancer method. Formerly studied the proof, the oviduct ligation may also reduce the ovarian cancer morbidity risk, but these person’s BRCA gene condition is not clear. The oviduct ligation was considered that is through prevents the carcinogen upward to have an effect along the feminine genital tract.
Narod and so on this research material from British, American and Canada’s several Research center. The object of observation to have BRCA1 or 2 gene mutation attack ovarian cancer patient, the control group to have the above gene mutation but not to have the ovarian cancer. Two group of objects of observation in age, geographical position, race and BRCA sudden change type aspect not remarkable difference. Altogether integrates 232 pair of appropriate matches the objects of observation, uses the questionnaire survey understanding birth history, the oral contraceptive application situation and the oviduct ligation material. The control group breast cancer history, oral contraceptive Shi Jiping divides property equally many time.
The result showed that 75% cases compare to have the BRCA1 gene mutation. Has ovarian cancer patient who BRCA1 changes suddenly, is the oviduct fastening to be more remarkable than few control group, in after the application oral contraceptive, produces the time and the race carry on the adjustment, two groups of differences still had the significance. Oviduct ligation as if to BRCA2 gene mutation woman protective function. The pure oral contraceptive has the protective function to BRCA1 and the BRCA2 gene mutation (ratio to compare respectively is 0.48 and 0.35). The oral contraceptive adds the oviduct ligation protective function to be biggest. The oviduct ligation may cause the BRCA1 gene mutation ovarian cancer risk to reduce 61%, but the oral contraceptive adds the oviduct ligation to be possible to cause this crowd ovarian cancer risk to reduce 72%.
This case compares the research discovery, the oviduct ligation has the protective function to the BRCA1 gene mutation woman. The case and the collator are match, but the two still had some important differences. The known pregnancy and may reduce the ovarian cancer danger using the oral contraceptive, the control group uses the oral contraceptive to be many. Moreover, the collator produces time are also many. But the multivariable analysis demonstrated that the oviduct ligation has the independent protective function. The control group once contracted breast cancer to be also many. The BRCA gene mutation woman contracts breast cancer danger also to increase, but is very at present difficult to determine between the ovarian cancer and breast cancer’s relations, moreover the multivariable analysis indicated that breast cancer has nothing to do with the oviduct ligation’s protective function.
This findings have provided another precautionary approach for the high-risk ovarian cancer patient, even if reduces the danger 50%, they contracted ovarian cancer’s danger to be very still big. Although the preventive ovary excision method may reduce the ovarian cancer danger, but the oral contraceptive and the tubal ligation may postpone the surgery time, improvement high-risk woman’s quality of life.
