Some gene mutations can increase the risk that the women suffer from an ovary cancer and Narod etc. carried on a case control study, discover that a pair of sides tubal ligations can lower BRCA1 a mutation women to suffer from the danger of ovary cancer.
The women suffer from encroaching upon a sex ovary cancer of the whole life dangerous is 1/70.The one who take some mutant genes(BRCA1 or BRCA2)s suffers from an ovary cancer dangerous obviously increase(40% and 25%).Usually younger while there are the women of these mutations being diagnose for the ovary cancer and be placed in disease for later period.Up to the present still have no the dependable method of screening ovary cancer, particularly to Menopause ex- women.The research expresses that the oral contraceptive drugs can lower to have or have no these mutation women’s ovary cancer dangers.Prevent°from sex ovariectomy be the gene mutation of a lot of BRCA1s or BRCA2 women, can choose after the completion grow of another one the species prevention ovary cancer method.Study a certificate before, the tubal ligation can also reduce the ovary cancer outbreak risk, but these people’s BRCA gene condition be not clear.The tubal ligation is think to pass to keep carcinogen from follow a female reproduction way the north bound but vesication action.
That research data of Narod etc. is a few research centers from England, the United States and Canada.Observe object in order to have the sex ovary cancer of the encroach upon of the gene mutations of the BRCA1?2s the sufferer, matched control for have the above-mentioned gene mutation but have no ovary cancer.Two section observation the object all didn’t show Zhao difference in age, geography position, race and BRCA mutation type.Totally bring into 232 rightnesses of observation objects for match each other, adoption questionnaire understanding grows a history, applied circumstances and tubal ligation data of oral contraceptive drugs.The matched control breast carcinoma history, oral contraceptive drugs history and average para are more.
Show that 75% cases check against as a result to exist BRCA1 gene mutation.There is BRCA1 the ovary cancer of the mutation sufferer, do a tubal ligation to show Zhao than the matched control little, is having already shown Zhao towards applying oral contraceptive drugs, para and race to carry on a correction after, two section differences still.The tubal ligation seems to be gene mutation women and doesn’t protect an action to the BRCA2.The pure oral contraceptive drugs all has protection action to the gene mutations of BRCA1 and BRCA2.(specific value score don’t be 0.48 demulcent therapy, reconciliation 0.35)The oral contraceptive drugs adds a tubal ligation protection an action biggest.The tubal ligation can make the ovary cancer risk of the BRCA1 gene mutation lower 61%, but the oral contraceptive drugs add a tubal ligation and can make that crowd ovary cancer risk lower 72%.
That case control study discover that tubal ligation to BRCA1 gene mutation the women have a protection action.Case and collator match very much, but twos still exist some important differences.Have already known that pregnancy and application oral contraceptive drugs can lower ovary cancer danger, the matched control uses an oral contraceptive drugs more.Moreover, the collator para is also more.But much change to measure an analytical manifestation, the tubal ligation contains independent protection action.Matched control’s once suffering from a breast carcinoma is more.The women of BRCA gene mutation suffer from a breast carcinoma dangerous also increase, but very difficult certain currently the relation between ovary cancer and of breast carcinoma, and much change to measure analysis enunciation, the breast carcinoma has nothing to do with the protection action of tubal ligation.
That research effect for high risk ovary carcinomatosis the person provided another a species a prevention a method, but even reduced danger to 50%, they suffered from the danger of ovary cancer still very big.Although the prevention ovariectomy can lower ovary cancer danger,oral contraceptive drugs and tubal ligation Shu can postpone surgical operation for time, the women’s living quality of the improvement high risk.
