Ovary cancer overview
The ovary epithelioma is one species opposite and seldom seen gynecology tumor in the United States, about have 25580 new outbreak sufferers in 2004 and 16090 sufferer die.Most patients is later period cancers and treat a way to cut off for the surgical operation and post-operative take platinum as the chemotherapy of basal.The past 10 year period, the improvement of chemotherapy project raised a survival rate, and more effective to the treatment of relapse tumor.In addition Be to the method which inherits thorough understanding of dangerous factor to make to adopt individualization in the prevention the strategy come carrying on a pair of sides fallopian tube-ovariectomy in the women.The feature with epithelial and clinical ovary of the this overview report way, the point report doctrine treats behind of the latest progression.
Epidemiology and dangerous factor
The ovary epithelioma derive from and the bad mutation of the continuous ovary superficial epithelium, germinal epithelium of the phase of peritoneum mesothelium.The medium age of ovary cancer sufferer is 60 years old, the women are about equally the whole life dangerous 1/70.Explicit ovary cancer or breast carcinoma kindred history are the most important dangerous factors, though only about 5%ly implicate women win can the detection inherit an easy nasty.The nullipara and ovary cancer is dangerous the increment be related, but the oral contraceptive drugs, pregnancy, lactation have something to do with danger lower.In fine, these observation research express that growing a drug can increase ovary cancer danger, but through para demulcent therapy, reconciliation not the anaphase of the empress of the partition correction the research didn’t confirm these effect.The women who accept tubal ligation Shu seem to compare don’t the women of the surgical operation outbreak dangerous low, though the mechanism is still not clear.
The kindred synthesizes a disease
In the meantime or there are explicit breast carcinoma and the ovary cancer kindred history(sometimes is take place in the same of women young) respectively, probably is BRCA1 and BRCA2 with two genes.BRCA1 and BRCA2 genes are located on the chromosome 17 q and 13 qs respectively and their genes outcome involves a DNA repair.Because BRCA1 and BRCA2 mutate of the allele, allelomorph may inherit from any one square of parents, at dangerous valuation the period obtain a complete kindred history very important.
Particular race colony, for example the Judean philtrum in the North Europe, implicit germ line BRCA1 and BRCA2 mutate of possibility increment.Healthy North Europe Jew women win the most familiar of 3 species mutations be the 185 delAG of the BRCA1s mutation, the 5382 insC on the BRCA1 mutation, the 6174 delT on the BRCA2 mutation, the total incidence rate is about 2.5%.However be up to 26% ?s 41% according to the incidence rate of report way this kind of mutation in the North Europe Judean women confirm ovary cancer.According to the report way, the women who have the BRCA1 germ line mutation suffer from the whole life dangerous scope of ovary cancer as 56% ?s 87%.Though know the BRCA1 germ line mutation a carrier can count for much at the any age occurrence ovary cancer, but BRCA1 germ line mutation the women’s ovary cancer outbreak the age ratio send forth a sufferer sterigma.
Like the BRCA1, BRCA2 proteinases are located on a nucleus and pass to combine with the proteinase RAD51 to participate a DNA repair.The BRCA2 germ line mutation women suffer from a breast carcinoma of the whole life dangerous mutate a carrier with BRCA1 likeness, they suffer from an ovary cancer of the whole life dangerous about is 10%.The male, who compare BRCA1 or BRCA2 mutations with the one who have no mutation, has already suffered from a breast carcinoma is dangerous, the danger which suffers from a pancreas cancer may also increase.With send forth a sufferer to compare, in BRCA1 or the BRCA2 germ line mutation crowd ovary cancer sufferer the feature of history of the natural disease is a course of illness progression more slow-moving.
Ovary cancer augmentatively the second dangerous house series disease is a Lynch syndrome ? ;That disease from DNA mismatch repair gene, such as the heredity of the MSH2(mutS congener 2) or the MLH1(mutL congener 1) not poplypus colon cancer, usually involve in right side colon, sometimes the companion contain other cancers, for example corpus uteri cancer, ovary cancer or reproduction urinary tract tumor.
The prevention of BRCA1 or the BRCA2 germ line mutation women treat
Have already known the women who there is BRCA1 or the BRCA2 germ line mutation, the completion after grow the function can pass an excision double side fallopian tube ovary but lower occurrence ovary the danger of the cancer, in this kind of case, this is to choose of one the species prevention method.Because the mutation carrier suffers from the danger of fallopian tube cancer to also go up, so suggest to cut off fallopian tube as to prevent°from sex surgical operation of a fraction, some scholars for insure complete cut off the fallopian tube still consider going a hysterectomy.Although prevention double the side salpingo-ovariectomy can lower the danger of ovary cancer, BRCA1 and the BRCA2 germ line mutation the sufferer apparently has already suffer from to deliver the keep on of cancer of sex peritoneum syrup liquid danger at first and that disease can take place after prevent°from sex surgical operation.For example, in a review research, Piver etc. the report way once accepted a prevention ovariectomy during 1-27 years of 6 occurrence deliver a sex peritoneum syrup liquid a cancer at first in the middle of 324 women.This kind of disease at clinical demulcent therapy, reconciliation histology up similar was think to represent the surface of peritoneum mesothelium at the ovary epithelioma of bad change.According to report way BRCA1, and BRCA2 germ line mutation the women prevent sex from cut off a pair of sides fallopian tubes ovary, can lower the outbreak of breast carcinoma dangerous, calculate its reason may be in the meantime or respectively lowered circulation medium estrogenic hormone and progestogen level.Correspond ground, whether post-operative women should accept estrogenic hormone complement to treat to still have a controversy at present or not.The discussion was other to lower the dangerous strategy of the breast carcinoma outbreak to outrun the scope of this overview, for example carry on sieving in the high risk group, the prevention mastectomy or prevention chemotherapy.Don’t wish to accept a pair of women whom the ovary prevention of sides fallopian tubes cut off towards having an ovary cancer the high risk factor but, should consider carrying on a screening, include usually sexual basin antrum a check, serum CA 125 determination demulcent therapy, reconciliation through vagina basin antrum super voice check.However, have to what to emphasize BE, these screening strategies usually leak an ovary cancer of diagnose the earlier period, and carry on an ovary cancer in the high risk group and the efficacy of the screening not yet gets a confirmation.Same of, for have a general ovary cancer the women of the danger but talk(namely have never had already know the women of the inheritance easy nasty), still have no explicit proof enunciation to include in the meantime or measurese levels and basin of the serum CA125 antrum a super voice a check respectively at inside of the normal regulations screening beneficial place.Currently at least 2 under way the random clinical studies carry on valuation in the action in the ovary cancer to the screening.End use since low ovary cancer dangerous advantage of the oral contraceptive drugs indetermination still in the mutation the carrier.Modan etc. report way the prevention uses an oral contraceptive drugs in BRCA1 or the BRCA2 germ line mutation the women also of no avail, but Narod etc. of the earlier period study to hint then that the oral contraceptive drugs may benefit.
