The epithelium ovary cancer mechanism explore clear
Once the river south medicine department university attach professor’s Joe’s jade bracelet, the graduate student Guo Rui Xia of hospital gynecology to wait for someone to study to discover recently, some amplification or excesssive expression of the tumor suppressor gene are an ovary cancer occurrence of key factor.This is the research result of “the epithelium carcinomatous change mechanism of the ovary tumor and its clinical application research” and acquire “science and technology progress accessit” in Henan recently.
The ovary cancer is a female one of the familiar malignant tumors, 5 year, survival rate only 25% be or so.The its cardinal reason is relatively a clinical outbreak to hide and lacked specificity to be taken bad digit to advertise for in early days.The recent years research hints that the excrescent enzyme amplification of ovary epithelial cell may be the ovary cancer at the earliest stage expect of the occurrence change.Joe jade bracelet professor etc. application the immunity section turn the technique ABC method and analyzed 35 normal ovary tissue, 21 cystadenomas, 40 epithelium ovary cancers and 19 example correspond greater omentum transfer cooking stove etc. the tumor suppressor gene maspin, p in the tissue 53 demulcent therapy, reconciliation the tumor transfer suppressor gene nm 23 in the ovary carcinomatous change turn the process of variety regulation, and these variety and cellular hyperplasia change, such as cell proliferation nucleosidase antigen(PCNA) of relation.Show as a result:Arrive to hand over a kingdom a tumor to the ovary cancer from the normal ovary, adenoma, the PCNA marking index number enlarges with the go up of ovary cancer histology Class;The maspin expression of different type ovary tissue is consistently basic, the maspin expression rate shows Zhao in the cancer tissue low in normal ovary epithelium, adenoma and hand over the kingdom tumor maspin expression rate, and go up but descend with the ovary cancer histology Class;Strach the p of the liquid ovary cancer 53 male expression rates to show Zhao Gao at the mucus cancer and mucous membrane, endometrium kind cancer, go up along with the Class of ovary histology, p 53 marking index numbers enlarge gradually;Ovary cancer and it corresponds the above-mentioned gene expression of the cooking stove of greater omentum transfer and doesn’t show Zhao difference.
The above effect prove:The PCNA can reflect the malignancy degree of ovary cancer to some extent, and have certain value to understand its occurrence development process and good malignant pathological changes;The maspin gene is another importance in the ovary cancer occurrence process of molecule enzymology change, present a positive correlation with the differentiation degree of the ovary cancer;Nm 23 genes have relation with ovary cancer occurrence, in the ovary cancer cell differentiation process is regulate an action;P 53 gene mutations are strach the occurrence development of the liquid ovary cancer to like righteousness bigger, present a positive correlation with the ovary cancer histology fractionation;P 53 present a straight line positive correlation with PCNA marking index number, but nm 23 demulcent therapy, reconciliation maspin and cell proliferation present a negative correlation.
Sep
02
By: Gelais
In: Ovarian Cancer | Permalink
