Treatment of recurrent urinary tract infections
If treatment minute of urinary tract infection is currently low therapy of choice, it does not prevent recidivism in a more or less long term bladder infections in some women.
Faced with repeated urinary tract infections, it is required to prescribe prophylactic antibiotics.
What product use, what dose and how fast?
Three families of compounds are commonly used in the prophylaxis of the disease urinary:
- Nitrofurantoin (FURADANTINE)
- Sulfametoxazole-trimethoprime (BACTRIM)
- And quinolone (PEFLACINE, NOROXINE etc.)
Before the arrival on the pharmaceutical market of quinolones, the first two have been the subject of several studies showing a comparable decrease in the number of infections compared to placebo. But for the same result, it is enough to give the BACTRIM twice a week against one capsule daily FURADANTINE.
A few years later, the use of quinolone shows a genuinely effective since daily dose of 200 mg of norfloxacin enough to eliminate any recurrence over a period of one year, while two-thirds of the control group will present at least one episode of infection.
This molecule seems to have an effect greater than nitrofurantoin since in a randomized, 81% of patients treated with 200 mg daily norfloxacin abuse testing on an observation period of one year, whereas in the group nitrofurantoin the rate of non - - repeat offenders is only 65%.
The rates of side effects are identical.
These repeated urinary tract infections are often related to sex life. A dose of postcoital quinolone is as effective as a daily routine treatment. On average ingestion of the amount of drug in the group “postcoital” is the third of the amount the group “systematic”.
More recent studies and on a large number of patients showed that the drug doses can be reduced to a weekly prize with less than 10% of recurrences.
In all these studies, it has not been shown to bacterial resistance and improving clinical and bacteriological continues beyond the cure.
For the record, estrogen treatment and the provision of vaginal lactobacilli have no positive effect on the disease.
